Revised diagnosis and severity criteria for SOS/VOD

Posted on: 8 Aug 2016

This report marks an important development in the management of SOS/VOD that aims to allow early detection, with the goal of earlier treatment and improved outcomes, abstract below and full article in the learning section


Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (40%). There fore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licenced for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Bone Marrow Transplantation (2016) 51, 906912; doi:10.1038/bmt.2016.130; published online 16 May 2016